Exclusion criteria were as follows: 1, diagnosis of brain abscess and other infectious diseases before surgery 2, diagnosis of brain abscess or inflammation after surgery 3, death or discharged for various reasons within 2 days after surgery.ģ.4. Inclusion criterion was having intracranial infection (including meningitis, ventriculitis, brain abscess, as well as subdural and epidural abscess) after surgery. After having intracranial infection, their consciousness was gradually weakened, and 9 patients had severe disturbance of consciousness, accompanied by symptoms, such as vomiting and headache. All patients had fever symptoms, with body temperatures of 38☌ to 40.5☌. There were 26 cases of cerebrovascular disease, 17 cases of traumatic brain injury, 38 cases of intracranial tumor, 22 cases of spinal cord lesion, and 17 cases of hydrocephalus. Clinical Data for Selection of Antibacterial AgentsĪ total of 120 patients, who received neurosurgery at the hospital of this study, between January 2015 and June 2016, were selected, including 63 males and 57 females aged between 10 and 75 years old (49.32 ± 4.21). The CSF samples were mainly collected from patients diagnosed with intracranial tumors, cerebral hemorrhage, cerebral vascular malformations, subarachnoid hemorrhage, and intra-spinal tumors.ģ.3. Clinical Data for Bacterial Classificationīacteria were collected from CSF cultures of all patients receiving neurosurgery at the department of neurosurgery, Jinhua and Wenzhou Hospital, between January 2013 and December 2015, and the same kinds of strains cultured from each case during the same infection were combined. This study was approved by the ethics committee of the study hospital (code number: JCCH-20130105), and written consent was obtained from all patients.ģ.2. Based on the results, similar cases from January 2015 to June 2016 were effectively treated by rationally selecting antibacterial agents. Thereby, motivated to explore the distribution of pathogenic bacteria upon intracranial infection after neurosurgery and considering changes of resistance to antibacterial agents, the cerebrospinal fluid (CSF) bacterial cultures from infected patients from January 2013 to December 2015 were retrospectively analyzed. As a result, anti-infective treatment has become troublesome owing to aggravated resistance to antibacterial agents ( 10). In the presence of the blood-brain barrier, high-dose anti-infective drugs are required to treat intracranial infection for a long time. The drug resistance of pathogenic bacteria, especially Staphylococcus aureus, is increasing annually, also hindering effective clinical treatment ( 9). reported an intraventricular tigecycline therapy for intracranial infection with extremely drug resistant Acinetobacter baumannii, which was rather problematic because of multidrug resistance and difficult penetration through the blood-brain barrier ( 8). reported that intracranial infections after craniotomy were mostly induced by methicillin-resistant staphylococci ( 7). Mostly caused by trauma, surgery, blood-borne abscesses, parasitic diseases, granulomas and tuberculosis ( 5), intracranial infection commonly occurs within 3 to 7 days after surgery ( 6).īy evaluating the effects of intraventricularly administered vancomycin, Chen et al. The pathogens for intracranial infection may be bacteria, viruses, parasites, mycoplasma, chlamydia, mold, and rickettsia ( 4). It is mainly manifested as meningitis, cerebritis, brain abscess, etc. Intracranial infection after neurosurgery is amongst serious complications, with incidence rates of 1.52% to 6.6% ( 1, 2). Patients mostly have critical illness, various degrees of disturbance of consciousness, long surgical time, high surgical difficulty, etc., thus they are prone to infection. Neurosurgery has mainly been used to treat cerebral hemorrhage diseases, brain tumors, and traumatic brain injury. Neurosurgery Intracranial Infection Cerebrospinal Fluid Pathogenic Bacteria Antibacterial Agents 1. vancomycin and linezolid) using HIS were satisfactory, the findings of retrospective analysis are of high clinical value. Since the treatment outcomes after rational selection of antibacterial agents (i.e.
0 kommentar(er)
